Comparison of Postoperative Nausea and Vomiting Incidence between Remimazolam and Sevoflurane in Tympanoplasty with Mastoidectomy: A Single-Center, Double-Blind, Randomized Controlled Trial

Background and Objectives: Postoperative nausea vomiting (PONV) is a common adverse effect of general anesthesia, especially in middle ear surgery. Remimazolam newer benzodiazepine recently approved for use anesthesia. This study aimed to compare the incidence rate PONV after tympanoplasty with mastoidectomy between using remimazolam sevoflurane. Materials Methods: included 80 patients undergoing elective mastoidectomy. The were randomly assigned either or sevoflurane group. primary outcome was 12 h secondary outcomes 12–24 24–48 surgery, severity PONV, vomiting, administration rescue antiemetics, hemodynamic stability, recovery profiles. Results: 0–12 significantly lower group compared that (28.9 vs. 57.9%; p = 0.011). However, delayed did not differ two groups. early periods surgery than events group, but there no difference overall trends data There profiles Conclusions: can reduce under